Hoxb8^tm1.1Jdes
Targeted Allele Detail

Summary

• Symbol: Hoxb8^tm1.1Jdes
• Name: homeobox B8; targeted mutation 1.1, Jacqueline Deschamps
• MGI ID: MGI:1934178
• Synonyms: Hoxb8lacZneo^-
• Gene: Hoxb8 Location: Chr11:96172731-96176141 bp, + strand Genetic Position: Chr11, 59.82 cM
• Alliance: Hoxb8^tm1.1Jdes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58621
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele is a derivative of Hox8b^tm1Jdes in which a Cre-mediated recombination event in the germline excised a floxed neomycin/thymidine kinase cassette that had been inserted downstream of a beta-galactosidase gene in the first exon. (J:58621)

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb8 Mutation: 8 strains or lines available

References

• Original: J:58621 van den Akker E, et al., Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. Mech Dev. 1999 Dec;89(1-2):103-14
• All: 5 reference(s)