Runx1^tm1Sata
Targeted Allele Detail

Summary

• Symbol: Runx1^tm1Sata
• Name: runt related transcription factor 1; targeted mutation 1, Masanobu Satake
• MGI ID: MGI:1934197
• Synonyms: AML1(-), Runx1^-
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm1Sata page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50937
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced by a PGK-neo cassette. The deleted region encoded the central portion of the conserved DNA-binding domain. Transcript was undetectable by RT-PCR analysis of extracts from the yolk sacs, livers, and aorta-mesonephros regions of homozygous mutant embryos. (J:50937)

Expression

In Mice Carrying this Mutation:	154 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:50937 Okada H, et al., AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998 Nov 5;17(18):2287-93
• All: 19 reference(s)