Pitx1^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Pitx1^tm1Rsd
• Name: paired-like homeodomain transcription factor 1; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:1934200
• Gene: Pitx1 Location: Chr13:55972864-55984005 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Pitx1^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53310
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the homeodomain and most of the 3' coding sequence of this gene were replaced with a lacZ/neo-derived cassette via homologous recombination. (J:53310)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx1 Mutation: 11 strains or lines available

References

• Original: J:53310 Szeto DP, et al., Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev. 1999 Feb 15;13(4):484-94
• All: 7 reference(s)