Gab1^tm1Wbm
Targeted Allele Detail

Summary

• Symbol: Gab1^tm1Wbm
• Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 1, Walter Birchmeier
• MGI ID: MGI:1934204
• Synonyms: gab1^-
• Gene: Gab1 Location: Chr8:81491067-81607148 bp, - strand Genetic Position: Chr8, 38.47 cM, cytoband C3
• Alliance: Gab1^tm1Wbm page

Cleft palate in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm, Gab1^tm1Wbm/Gab1^tm1Wbm and Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ mice, but not in Gab1^tm4Wbm/Gab1^tm4Wbm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68751
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene was fused in frame to sequences encoding the N-terminal plekstrin homology domain, followed by a neomycin selection cassette. Western blot analysis on extracts of homozygous E12.5 embryos confirmed that no detectable GAB1 protein was expressed from this allele. (J:68751)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gab1 Mutation: 78 strains or lines available

References

• Original: J:68751 Sachs M, et al., Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol. 2000 Sep 18;150(6):1375-84
• All: 5 reference(s)