Gfra1^tm1Rosl
Targeted Allele Detail

Summary

• Symbol: Gfra1^tm1Rosl
• Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 1, Arnon Rosenthal
• MGI ID: MGI:1934205
• Synonyms: gfra1-
• Gene: Gfra1 Location: Chr19:58224036-58444341 bp, - strand Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
• Alliance: Gfra1^tm1Rosl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68750
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 2, resulting in the deletion of amino acids 14 - 66. In situ hybridization using an exon 2-specific probe, showed no detectable transcripts in homozygous mutant mice. (J:68750)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra1 Mutation: 33 strains or lines available

References

• Original: J:68750 Cacalano G, et al., GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron. 1998 Jul;21(1):53-62
• All: 10 reference(s)