Cripto^tm1Mms
Targeted Allele Detail

Summary

• Symbol: Cripto^tm1Mms
• Name: cripto, EGF-CFC family member; targeted mutation 1, Michael M Shen
• MGI ID: MGI:1934206
• Synonyms: Cripto-, Cripto^lacZ
• Gene: Cripto Location: Chr9:110768676-110775226 bp, - strand Genetic Position: Chr9, 60.79 cM
• Alliance: Cripto^tm1Mms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50343
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced by a contstruct containing a promoterless lacZ and PGK-neo. Beta-galactosidase staining of heterozygous embryos showed the expression pattern of the lacZ gene to lag that of the endogenous gene. (J:50343)

Expression

In Mice Carrying this Mutation:	123 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cripto Mutation: 55 strains or lines available

References

• Original: J:50343 Ding J, et al., Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo [see comments]. Nature. 1998 Oct 15;395(6703):702-7
• All: 11 reference(s)