C5ar1^tm1Cge
Targeted Allele Detail

Summary

• Symbol: C5ar1^tm1Cge
• Name: complement component 5a receptor 1; targeted mutation 1, Craig Gerard
• MGI ID: MGI:1934246
• Synonyms: C5aR-, C5aRKO
• Gene: C5ar1 Location: Chr7:15980668-15993465 bp, - strand Genetic Position: Chr7, 8.77 cM
• Alliance: C5ar1^tm1Cge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69177
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the entire coding region of the gene. Northern analysis of bone marrow cells did not detect expression in homozygous mutant mice. (J:69177)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any C5ar1 Mutation: 31 strains or lines available

References

• Original: J:69177 Hopken UE, et al., The C5a chemoattractant receptor mediates mucosal defence to infection. Nature. 1996 Sep 5;383(6595):86-9
• All: 148 reference(s)