Ihh^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Ihh^tm1Amc
• Name: Indian hedgehog; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:1934258
• Synonyms: Ihh^-, Ihhⁿ
• Gene: Ihh Location: Chr1:74984474-74990831 bp, - strand Genetic Position: Chr1, 38.55 cM
• Alliance: Ihh^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57297
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire first exon, which encodes much of the signaling peptide, and approximately 1kb of flanking sequence. (J:57297)

Disease models

Expression

In Mice Carrying this Mutation:	230 assay results
In Structures Affected by this Mutation:	32 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ihh Mutation: 22 strains or lines available

References

• Original: J:57297 St-Jacques B, et al., Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation [published erratum appears in Genes Dev 1999 Oct 1;13(19):2617]. Genes Dev. 1999 Aug 15;13(16):2072-86
• All: 49 reference(s)