Trp63^tm1Fmc
Targeted Allele Detail

Summary

• Symbol: Trp63^tm1Fmc
• Name: transformation related protein 63; targeted mutation 1, Frank McKeon
• MGI ID: MGI:1934269
• Synonyms: p63-, p63 KO, Tp63^-
• Gene: Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm1Fmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54637
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6, 7, 8, encoding sequences corresonding to the DNA-binding domain, and the intervening introns were replaced by a neomycin gene. (J:54637)

Disease models

Expression

In Mice Carrying this Mutation:	33 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	44 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp63^tm1Fmc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:54637 Yang A, et al., p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999 Apr 22;398(6729):714-8
• All: 37 reference(s)