Prnp^tm1Miy
Targeted Allele Detail

Summary

• Symbol: Prnp^tm1Miy
• Name: prion protein; targeted mutation 1, Tsutomu Miyamoto
• MGI ID: MGI:1934272
• Synonyms: Nagasaki, Ngsk Prnp⁰, Prnp^-, PrP
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^tm1Miy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69186
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence of the gene was replaced with a neomycin cassette. No mRNA was detected in the brains of homozyogous mutant mice by either Northern blotting or by in situ hybridization. (J:69186)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 142 strains or lines available

References

• Original: J:69186 Sakaguchi S, et al., Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent. J Virol. 1995 Dec;69(12):7586-92
• All: 24 reference(s)