Prnp^tm1Rcm
Targeted Allele Detail

Summary

• Symbol: Prnp^tm1Rcm
• Name: prion protein; targeted mutation 1, Richard C Moore
• MGI ID: MGI:1934273
• Synonyms: Prnp^a[108F189V], PrP gtB
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^tm1Rcm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45908
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The 129P2/OlaHsd strain normally carries the PrP A allotype, with leucine and threonine at residues 108 and 189. In this allele, the sequences encoding these amino acids were altered to instead encode phenylalanine and valine. These changes alter the allotype to one identical to PrP B. (J:29021)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 142 strains or lines available

References

• Original: J:45908 Moore RC, et al., Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent [see comments]. Nat Genet. 1998 Feb;18(2):118-25
• All: 4 reference(s)