Pax6^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Pax6^tm1Pgr
• Name: paired box 6; targeted mutation 1, Peter Gruss
• MGI ID: MGI:1934347
• Synonyms: Pax6-lacZ, Pax6^lacZ, Pax6::lacZ
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40439
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The start codon in exon 4 and the entire paired domain of Pax6 was replaced with a beta-galactosidase gene followed by a neomycin cassette. Beta-galactosidase was expressed in embryos in a pattern identical to Pax6. (J:40439)

Expression

In Mice Carrying this Mutation:	158 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 94 strains or lines available

References

• Original: J:40439 St-Onge L, et al., Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature. 1997 May 22;387(6631):406-9
• All: 43 reference(s)