Cxcl12^tm1Tng
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1Tng
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1, Takashi Nagasawa
• MGI ID: MGI:1934384
• Synonyms: PBSF/SDF-1-, SDF-1-
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1Tng page

Cerebellum defects in Cxcr4^tm1Qma/Cxcr4^tm1Qma and Cxcl12^tm1Tng/Cxcl12^tm1Tng mice.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34750
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 2 and flanking intronic sequences with a neomycin cassette. RT-PCR studies using primers that bracket exon 2 did not detect transcript in homozygous mutant E16.5 embryos. (J:34750)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 25 strains or lines available

References

• Original: J:34750 Nagasawa T, et al., Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996 Aug 15;382(6592):635-8
• All: 32 reference(s)