Cxcr4^tm1Tng
Targeted Allele Detail

Summary

• Symbol: Cxcr4^tm1Tng
• Name: C-X-C motif chemokine receptor 4; targeted mutation 1, Takashi Nagasawa
• MGI ID: MGI:1934442
• Synonyms: CXCR4-
• Gene: Cxcr4 Location: Chr1:128515936-128520030 bp, - strand Genetic Position: Chr1, 56.43 cM
• Alliance: Cxcr4^tm1Tng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69256
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced most of exon 2 including all of the sequences encoding the transmembrane regions. RT-PCR of E18.5 embryos did not detect transcript in liver tissue from homozygous animals. (J:69256)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcr4 Mutation: 46 strains or lines available

References

• Original: J:69256 Tachibana K, et al., The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998 Jun 11;393(6685):591-4
• All: 29 reference(s)