Socs2^tm1Wehi
Targeted Allele Detail

Summary

• Symbol: Socs2^tm1Wehi
• Name: suppressor of cytokine signaling 2; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:1934557
• Synonyms: SOCS-2-
• Gene: Socs2 Location: Chr10:95221224-95253042 bp, - strand Genetic Position: Chr10, 49.35 cM
• Alliance: Socs2^tm1Wehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63006
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced by a beta-gal-PGK-neomycin resistance cassette in which the beta-galactosidase coding region was fused to the initiation codon. Northern analysis of ten organs did not detect transcript in homozygous mice. (J:63006)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs2 Mutation: 24 strains or lines available

References

• Original: J:63006 Metcalf D, et al., Gigantism in mice lacking suppressor of cytokine signalling-2. Nature. 2000 Jun 29;405(6790):1069-73
• All: 33 reference(s)