Inpp4a^wbl
Spontaneous Allele Detail

Summary

• Symbol: Inpp4a^wbl
• Name: inositol polyphosphate-4-phosphatase, type I; weeble
• MGI ID: MGI:1934584
• Gene: Inpp4a Location: Chr1:37338946-37449817 bp, + strand Genetic Position: Chr1, 15.46 cM
• Alliance: Inpp4a^wbl page

Mutation origin

• Strain of Origin: C57BL/6J-A^w

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The underlying mutation underlying this allele was determined to be a single nucleotide deletion (G at nucleotide position 744). The resulting frameshift creates a stop codon at amino acid position 263, truncating most of the 939 amino acid protein including the active site. (J:72427)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inpp4a Mutation: 55 strains or lines available

References

• Original: J:72427 Nystuen A, et al., A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron. 2001 Oct 25;32(2):203-12
• All: 6 reference(s)