Socs1^tm1Wehi
Targeted Allele Detail

Summary

• Symbol: Socs1^tm1Wehi
• Name: suppressor of cytokine signaling 1; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:1934607
• Synonyms: SOCS-1-
• Gene: Socs1 Location: Chr16:10601672-10603400 bp, - strand Genetic Position: Chr16, 5.81 cM
• Alliance: Socs1^tm1Wehi page

Phenotypic abnormalities in Socs1^tm1Wehi/Socs1^tm1Wehi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51281
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced by a beta-gal-PGK-neomycin resistance cassette in which the beta-galactosidase coding region was fused to the initiation codon. Northern analysis of thymus did not detect transcript in homozygous mice. (J:51281)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Socs1 Mutation: 30 strains or lines available

References

• Original: J:51281 Starr R, et al., Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14395-9
• All: 30 reference(s)