Flna^Dilp2
Chemically induced Allele Detail

Summary

• Symbol: Flna^Dilp2
• Name: filamin, alpha; dilated pupils 2
• MGI ID: MGI:1934627
• Synonyms: Gena379, GENA 379
• Gene: Flna Location: ChrX:73267067-73293426 bp, - strand Genetic Position: ChrX, 37.89 cM
• Alliance: Flna^Dilp2 page

Mutation origin

• Strain of Origin: (C3H/HeN x BALB/cAnN)F1
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutant was identified in an ENU mutagenesis screen at Harwell. A single T to A transversion is found in exon 44 at position 7164. This converts a tyrosine codon to a nonsense codon at position 2388 in the protein. (J:112274)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Flna Mutation: 19 strains or lines available

References

• Original: J:75964 Thaung C, et al., Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet. 2002 Apr 1;11(7):755-67
• All: 10 reference(s)