Lyz2^tm1(cre)Ifo
Targeted Allele Detail

Summary

• Symbol: Lyz2^tm1(cre)Ifo
• Name: lysozyme 2; targeted mutation 1, Irmgard Forster
• MGI ID: MGI:1934631
• Synonyms: LC, L^Cre, Lys-cre, LysCre, lysM/cre, LysMcre, LysM Cre, LysM-Cre, LysM^Cre, LysMCre, Lystm1(cre)Ifo, Lyz2-Cre, Lyz2Cre, Lyz-cre, LyzCre, (LyzM)-Cre
• Gene: Lyz2 Location: Chr10:117113446-117118177 bp, - strand Genetic Position: Chr10, 65.34 cM
• Alliance: Lyz2^tm1(cre)Ifo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67924
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Lyz2^tm1(cre)Ifo expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lyz2 (MGI:96897)

• Mutation details: An NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. (J:67924)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyz2 (mouse) Summary of all recombinase alleles driven by Lyz2. Comparative matrix view of recombinase activities Alliance mouse Lyz2 gene page

Disease models

Expression

In Mice Carrying this Mutation:	13 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lyz2^tm1(cre)Ifo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 14 strains available Cell Lines: 0 lines available
• Carrying any Lyz2 Mutation: 40 strains or lines available

References

• Original: J:67924 Clausen BE, et al., Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 1999 Aug;8(4):265-77
• All: 2581 reference(s)