Fcer2a^tm1Max
Targeted Allele Detail

Summary

• Symbol: Fcer2a^tm1Max
• Name: Fc receptor, IgE, low affinity II, alpha polypeptide; targeted mutation 1, Max-Planck-Institut fur Immunbiologie
• MGI ID: MGI:1934672
• Synonyms: CD23-, Fc epsilon RII
• Gene: Fcer2a Location: Chr8:3731737-3744175 bp, - strand Genetic Position: Chr8, 1.92 cM, cytoband A1
• Alliance: Fcer2a^tm1Max page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18952
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 3 and 4. Northern blot analysis did not detect mRNA in homozygous mutant spleen. Flow cytometric analysis did not detect membrane-bound protein in homozygous mutant spleen. (J:18952)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcer2a Mutation: 24 strains or lines available

References

• Original: J:18952 Yu P, et al., Negative feedback regulation of IgE synthesis by murine CD23. Nature. 1994 Jun 30;369(6483):753-6
• All: 16 reference(s)