Hspg2^tm1Nid
Targeted Allele Detail

Summary

• Symbol: Hspg2^tm1Nid
• Name: perlecan (heparan sulfate proteoglycan 2); targeted mutation 1, National Institute of Dental and Craniofacial Research
• MGI ID: MGI:1934891
• Synonyms: Hspg2^-
• Gene: Hspg2 Location: Chr4:137196080-137297941 bp, + strand Genetic Position: Chr4, 69.93 cM
• Alliance: Hspg2^tm1Nid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67299
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 7 of the gene, which encodes the N-terminus of the LDL-receptor-like domain of the protein. Northern blots of fibroblast RNA from homozygous mutant mice showed no detectable transcript for the targeted gene. (J:67299)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspg2 Mutation: 310 strains or lines available

References

• Original: J:67299 Arikawa-Hirasawa E, et al., Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999 Nov;23(3):354-8
• All: 12 reference(s)