Lamc1^tm1Edg
Targeted Allele Detail

Summary

• Symbol: Lamc1^tm1Edg
• Name: laminin, gamma 1; targeted mutation 1, David Edgar
• MGI ID: MGI:1934900
• Gene: Lamc1 Location: Chr1:153094668-153208532 bp, - strand Genetic Position: Chr1, 65.3 cM
• Alliance: Lamc1^tm1Edg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52418
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-betageo gene was inserted into exon 1. Northern blot analysis on doubly targeted ES cells demonstrated that no transcript was expressed from this allele. (J:52418)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamc1 Mutation: 143 strains or lines available

References

• Original: J:52418 Smyth N, et al., Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. J Cell Biol. 1999 Jan 11;144(1):151-60
• All: 2 reference(s)