Hs2st1^{Gt(pGT1.8TM)ST125Nimr}
Gene trapped Allele Detail

Summary

• Symbol: Hs2st1^{Gt(pGT1.8TM)ST125Nimr}
• Name: heparan sulfate 2-O-sulfotransferase 1; gene trap ST125, National Institute for Medical Research
• MGI ID: MGI:1934916
• Synonyms: Hs2st^LacZ, Hs2st^TgNSt125Nimr
• Gene: Hs2st1 Location: Chr3:144135467-144275942 bp, - strand Genetic Position: Chr3, 68.89 cM
• Alliance: Hs2st1^{Gt(pGT1.8TM)ST125Nimr} page

Mutation origin

• Mutant Cell Line: ST125
• Germline Transmission: Earliest citation of germline transmission: J:48481
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGTtm0 Vector Type: gene trap
• Mutation details: A gene trap vector inserted into the coding region of the gene at codon 588. Northern blot analysis demonstrated that a larger hybrid transcript was expressed from this allele, but this transript is not expected to express a functional protein. (J:48481)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hs2st1 Mutation: 33 strains or lines available

References

• Original: J:48481 Bullock SL, et al., Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev. 1998 Jun 15;12(12):1894-906
• All: 14 reference(s)