Lama5^tm1Jhm
Targeted Allele Detail

Summary

• Symbol: Lama5^tm1Jhm
• Name: laminin, alpha 5; targeted mutation 1, Jeffrey H Miner
• MGI ID: MGI:1934917
• Synonyms: Lama5 -
• Gene: Lama5 Location: Chr2:179818166-179867652 bp, - strand Genetic Position: Chr2, 102.7 cM
• Alliance: Lama5^tm1Jhm page

Syndactyly in Lama5^tm1Jhm/Lama5^tm1Jhm embryos

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51557
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame lacZ gene followed by a neomycin cassette replaced sequences encoding the N-terminal domains VI and V. Immunohistochemical analysis did not detect protein in distal limb basal lamina from homozygous mutant mice. (J:51557)

Expression

In Mice Carrying this Mutation:	46 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lama5 Mutation: 153 strains or lines available

References

• Original: J:51557 Miner JH, et al., Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain. J Cell Biol. 1998 Dec 14;143(6):1713-23
• All: 26 reference(s)