Sgca^tm1Kcam
Targeted Allele Detail

Summary

• Symbol: Sgca^tm1Kcam
• Name: sarcoglycan, alpha (dystrophin-associated glycoprotein); targeted mutation 1, Kevin P Campbell
• MGI ID: MGI:1934922
• Synonyms: alphaSG^-, KO/KO, Sgca^null, Sgca^tm594Kcam
• Gene: Sgca Location: Chr11:94853617-94867153 bp, - strand Genetic Position: Chr11, 59.01 cM, cytoband C
• Alliance: Sgca^tm1Kcam page

Sgca^tm1Kcam/Sgca^tm1Kcam mice display a progressive muscular dystrophy

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49992
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of 902 bp including exons 2 and 3 with a neomycin cassette. No mRNA was detectable in Northern blots of total RNA derived from skeletal muscle tissue of homozygous mutants, and no protein was detected in Western blots in membrane enriched preparations of skeletal muscle. (J:49992)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Sgca Mutation: 26 strains or lines available

References

• Original: J:49992 Duclos F, et al., Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. J Cell Biol. 1998 Sep 21;142(6):1461-71
• All: 32 reference(s)