Dcc^tm1Wbg
Targeted Allele Detail

Summary

• Symbol: Dcc^tm1Wbg
• Name: DCC netrin 1 receptor; targeted mutation 1, Robert A Weinberg
• MGI ID: MGI:1934924
• Synonyms: Dcc-, Dcc^X3
• Gene: Dcc Location: Chr18:71386705-72484140 bp, - strand Genetic Position: Chr18, 45.24 cM
• Alliance: Dcc^tm1Wbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39765
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 3. Immunoprecipitation experiments demonstrated that no full length protein was produced from this allele in homozygous mice. (J:39765)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dcc^tm1Wbg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dcc Mutation: 76 strains or lines available

Notes

Homozygous mutant mice have defective axonal projections of neural cells similar to those observed in null mutations for the netrin gene, Ntn1, but with no effects on intestine or on tumorigenesis within the intestine (J:39765).

References

• Original: J:39765 Fazeli A, et al., Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature. 1997 Apr 24;386(6627):796-804
• All: 74 reference(s)