Egfr^tm1Rdk
Targeted Allele Detail

Summary

• Symbol: Egfr^tm1Rdk
• Name: epidermal growth factor receptor; targeted mutation 1, Rik Derynck
• MGI ID: MGI:1935113
• Synonyms: EGF-R -
• Gene: Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
• Alliance: Egfr^tm1Rdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27464
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2, which encodes the amino terminal segment of the protein. (J:27464)

Expression

In Structures Affected by this Mutation:

29 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egfr Mutation: 87 strains or lines available

References

• Original: J:27464 Miettinen PJ, et al., Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 1995 Jul 27;376(6538):337-41
• All: 10 reference(s)