Slc12a2^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Slc12a2^tm1Ges
• Name: solute carrier family 12, member 2; targeted mutation 1, Gary E Shull
• MGI ID: MGI:1935144
• Synonyms: Nkcc1^-
• Gene: Slc12a2 Location: Chr18:58011750-58079893 bp, + strand Genetic Position: Chr18, 32.15 cM
• Alliance: Slc12a2^tm1Ges page

Slc12a2^tm1Ges/Slc12a2^tm1Ges mice exhibit growth retardation

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57651
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin gene into exon 6. Northern blot analysis of brain, heart, skeletal muscle, lung, kidney, stomach, small intestine and colon failed to detect any mRNA in homozygous mutants. (J:57651)

Expression

In Mice Carrying this Mutation:	156054 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc12a2 Mutation: 58 strains or lines available

References

• Original: J:57651 Flagella M, et al., Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J Biol Chem. 1999 Sep 17;274(38):26946-55
• All: 40 reference(s)