Abca1^tm1Jdm
Targeted Allele Detail

Summary

• Symbol: Abca1^tm1Jdm
• Name: ATP-binding cassette, sub-family A member 1; targeted mutation 1, John D McNeish
• MGI ID: MGI:1935192
• Synonyms: Abc1-, Abca1-, Abca1^-, ABCA1^-
• Gene: Abca1 Location: Chr4:53030787-53159895 bp, - strand Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
• Alliance: Abca1^tm1Jdm page

Pulmonary lesions in Abca1^tm1Jdm/Abca1^tm1Jdm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.7 kb genomic fragment containing exons 17-22 was deleted and replaced with a neomycin selection cassette. These sequences correspond to amino acids 788 to 1093 of the encoded protein. RT-PCR analysis on RNA derived from liver demonstrated that no detectable transcript was produced from this allele in homozygous mice. (J:61679)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abca1 Mutation: 90 strains or lines available

Notes

When used in bone marrow transplant into Ldlr^tm1Her homozygous mice, Abca1^tm1Jdm Abcg1^tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)

References

• Original: J:61679 McNeish J, et al., High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4245-50
• All: 84 reference(s)