Abca1^tm1Wpfl
Targeted Allele Detail

Summary

• Symbol: Abca1^tm1Wpfl
• Name: ATP-binding cassette, sub-family A member 1; targeted mutation 1, Wai-Ping Fung-Leung
• MGI ID: MGI:1935193
• Synonyms: ABCA1^-
• Gene: Abca1 Location: Chr4:53030787-53159895 bp, - strand Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
• Alliance: Abca1^tm1Wpfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64390
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.9 kb genomic fragment containing exons 19, 20 and part of 21 was deleted and replaced with a neomycin selection cassette. Northern blot and RT-PCR analysis indicated that a truncated transcript is produced from this allele, but any protein produced from this transcript is predicted to be nonfunctional. (J:64390)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca1 Mutation: 90 strains or lines available

References

• Original: J:64390 Christiansen-Weber TA, et al., Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency. Am J Pathol. 2000 Sep;157(3):1017-29
• All: 12 reference(s)