Pdgfrb^tm3Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm3Sor
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 3, Philippe Soriano
• MGI ID: MGI:2135532
• Synonyms: F2
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm3Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69710
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A to T transversions in the sequences corresponding to codons 739 and 750 were introduced that altered the corresponding amino acids from tyrosine to phenylalanine (Y739F, Y750F). This mutation is predicted to disrupt the PI3-K binding sites in the protein. A loxP flanked neomycin cassette was inserted into an adjacent intron. (J:69710)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 87 strains or lines available

References

• Original: J:69710 Heuchel R, et al., Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11410-5
• All: 6 reference(s)