Pdgfrbtm5Sor
Targeted Allele Detail
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Symbol: |
Pdgfrbtm5Sor |
Name: |
platelet derived growth factor receptor, beta polypeptide; targeted mutation 5, Philippe Soriano |
MGI ID: |
MGI:2135534 |
Synonyms: |
beta/alphaKI |
Gene: |
Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
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Alliance: |
Pdgfrbtm5Sor page
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Germline Transmission: |
Earliest citation of germline transmission:
J:67735
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Parent Cell Line: |
AK7 (ES Cell)
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Strain of Origin: |
129S4/SvJaeSor
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Allele Type: |
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Targeted (Inserted expressed sequence, No functional change) |
Mutation: |
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Insertion
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Mutation details: A cDNA encoding a chimeric receptor consisting of sequences encoding the extracellular portion of the PDGFbetaR fused to the intracellular portion of the PDGFalphaR was targeted into the Pdgfrb locus. The cDNA was inserted in frame into a Sma1 site in the second coding exon. Western blot analysis indicated that expression of the targeted Pdgfr locus was disrupted and the chimeric receptor was expressed.
(J:67735)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pdgfrb Mutation: |
87 strains or lines available
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Original: |
J:67735 Klinghoffer RA, et al., The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell. 2001 Feb;7(2):343-54 |
All: |
1 reference(s) |
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