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Pdgfrbtm5Sor
Targeted Allele Detail
Summary
Symbol: Pdgfrbtm5Sor
Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 5, Philippe Soriano
MGI ID: MGI:2135534
Synonyms: beta/alphaKI
Gene: Pdgfrb  Location: Chr18:61178222-61218133 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance: Pdgfrbtm5Sor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67735
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, No functional change)
Mutation:    Insertion
 
Mutation detailsA cDNA encoding a chimeric receptor consisting of sequences encoding the extracellular portion of the PDGFbetaR fused to the intracellular portion of the PDGFalphaR was targeted into the Pdgfrb locus. The cDNA was inserted in frame into a Sma1 site in the second coding exon. Western blot analysis indicated that expression of the targeted Pdgfr locus was disrupted and the chimeric receptor was expressed. (J:67735)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:  87 strains or lines available
References
Original:  J:67735 Klinghoffer RA, et al., The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell. 2001 Feb;7(2):343-54
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory