Pdgfrbtm6Sor
Targeted Allele Detail
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Symbol: |
Pdgfrbtm6Sor |
Name: |
platelet derived growth factor receptor, beta polypeptide; targeted mutation 6, Philippe Soriano |
MGI ID: |
MGI:2135535 |
Synonyms: |
betaKI |
Gene: |
Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
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Alliance: |
Pdgfrbtm6Sor page
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Germline Transmission: |
Earliest citation of germline transmission:
J:67735
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Parent Cell Line: |
AK7 (ES Cell)
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Strain of Origin: |
129S4/SvJaeSor
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Allele Type: |
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Targeted (Inserted expressed sequence, No functional change) |
Mutation: |
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Insertion
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Mutation details: A cDNA encoding PDGFbetaR was targeted into the Pdgfrb locus. This allele serves as a control for Pdgfrbtm5Sor. The cDNA was inserted in frame into a Sma1 site in the second coding exon. Western blot analysis indicated that expression of the targeted Pdgfr locus was disrupted and the introduced receptor was expressed.
(J:67735)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pdgfrb Mutation: |
87 strains or lines available
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Original: |
J:67735 Klinghoffer RA, et al., The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell. 2001 Feb;7(2):343-54 |
All: |
1 reference(s) |
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