Myf5^{tm1(Pdgfa)Sor}
Targeted Allele Detail

Summary

• Symbol: Myf5^{tm1(Pdgfa)Sor}
• Name: myogenic factor 5; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:2135563
• Synonyms: Myf5^PGDFA-N
• Gene: Myf5 Location: Chr10:107318769-107321995 bp, - strand Genetic Position: Chr10, 55.95 cM
• Alliance: Myf5^{tm1(Pdgfa)Sor} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65301
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A Pdgfa cDNA was inserted between a SacI site and a KpnI site in the 5'UTR of the Myf5 gene. An adjacent loxP-flanked neomycin cassette was retained in this allele. Alteration in the expression pattern of Pdgfa was noted in homozygous mutant embryos as assayed by in situ hybridization. (J:65301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myf5 Mutation: 17 strains or lines available

References

• Original: J:65301 Tallquist MD, et al., Early myotome specification regulates PDGFA expression and axial skeleton development. Development. 2000 Dec;127(23):5059-70
• All: 1 reference(s)