Myf5^{tm2(Pdgfa)Sor}
Targeted Allele Detail

Summary

• Symbol: Myf5^{tm2(Pdgfa)Sor}
• Name: myogenic factor 5; targeted mutation 2, Philippe Soriano
• MGI ID: MGI:2135564
• Synonyms: Myf5^PDGFA
• Gene: Myf5 Location: Chr10:107318769-107321995 bp, - strand Genetic Position: Chr10, 55.95 cM
• Alliance: Myf5^{tm2(Pdgfa)Sor} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65301
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A Pdgfa cDNA was inserted between a SacI site and a KpnI site in the 5'UTR of the Myf5 gene. An adjacent loxP-flanked neomycin cassette was removed via Cre mediated recombination in this allele. Alteration in the expression pattern of Pdgfa was noted in homozygous mutant embryos as assayed by in situ hybridization. (J:65301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myf5 Mutation: 17 strains or lines available

References

• Original: J:65301 Tallquist MD, et al., Early myotome specification regulates PDGFA expression and axial skeleton development. Development. 2000 Dec;127(23):5059-70
• All: 1 reference(s)