Car2ⁿ
Chemically induced Allele Detail

Summary

• Symbol: Car2ⁿ
• Name: carbonic anhydrase 2; null
• MGI ID: MGI:2135646
• Synonyms: CAII^-, CA(II)D, Car2^-, Car-2⁰, Car2N
• Gene: Car2 Location: Chr3:14951333-14965830 bp, + strand Genetic Position: Chr3, 3.23 cM
• Alliance: Car2ⁿ page

Morphological changes in the stomach and intestine of Car2ⁿ/Car2ⁿ and Car9^tm1Spas/Car9^tm1Spas mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: The result of ENU mutagenesis, the mutation at the Car2 locus is likely a nonsense or missense mutation. Molecular analysis shows that the mutant gene is not deleted but is transcribed. The CAR2 protein could not be detected by immunodiffusion analysis and Southern analysis indicates no detectable rearrangements or polymorphisms. (J:19268)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Car2 Mutation: 21 strains or lines available

References

• Original: J:19268 Lewis SE, et al., N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1962-6
• All: 30 reference(s)