Fgfr3^tm4.1Cxd
Targeted Allele Detail

Summary

• Symbol: Fgfr3^tm4.1Cxd
• Name: fibroblast growth factor receptor 3; targeted mutation 4.1, Chu-Xia Deng
• MGI ID: MGI:2135676
• Synonyms: Fgfr3^K644E
• Gene: Fgfr3 Location: Chr5:33879068-33894412 bp, + strand Genetic Position: Chr5, 17.83 cM, cytoband B
• Alliance: Fgfr3^tm4.1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63198
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mutation was introduced that altered codon 644 from one encoding lysine to one encoding glutamate (K644E). A loxP flanked neomycin cassette inserted into an adjacent intron was removed via Cre mediated recombination in this derivative of Fgfr3^tm4Cxd. (J:63198)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr3 Mutation: 54 strains or lines available

References

• Original: J:63198 Iwata T, et al., A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet. 2000 Jul 1;9(11):1603-13
• All: 6 reference(s)