Fgfr4^tm1Cxd
Targeted Allele Detail

Summary

• Symbol: Fgfr4^tm1Cxd
• Name: fibroblast growth factor receptor 4; targeted mutation 1, Chu-Xia Deng
• MGI ID: MGI:2135678
• Synonyms: FR4KO
• Gene: Fgfr4 Location: Chr13:55300631-55316572 bp, + strand Genetic Position: Chr13, 29.8 cM
• Alliance: Fgfr4^tm1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50677
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into exon 6, which encodes the IgII domain. No mRNA was detected in liver from homozygous mutant animals as assayed by Northern blot. Immunohistochemical analysis failed to detect protein in lungs from homozygous mutant mice. (J:50677)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr4 Mutation: 42 strains or lines available

References

• Original: J:50677 Weinstein M, et al., FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development. 1998 Sep;125(18):3615-23
• All: 29 reference(s)