Tac1^tm1Bbm
Targeted Allele Detail

Summary

• Symbol: Tac1^tm1Bbm
• Name: tachykinin 1; targeted mutation 1, Allan Basbaum
• MGI ID: MGI:2136170
• Synonyms: PPT-A-, PPTA^-, SPP^-
• Gene: Tac1 Location: Chr6:7555061-7562978 bp, + strand Genetic Position: Chr6, 3.31 cM
• Alliance: Tac1^tm1Bbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67563
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a PGK-neomycin resistance cassette into the gene replaced a coding region in exon 3 and deleted a coding region in exon 6. Immunoreactivity was not detected in the lumbar spinal cord of homozygous mutant mice. (J:67563)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tac1 Mutation: 41 strains or lines available

References

• Original: J:67563 Cao YQ, et al., Primary afferent tachykinins are required to experience moderate to intense pain. Nature. 1998 Mar 26;392(6674):390-4
• All: 59 reference(s)