Agrn^Gt(Ex192)Byg
Gene trapped Allele Detail

Summary

• Symbol: Agrn^Gt(Ex192)Byg
• Name: agrin; gene trap Ex192, BayGenomics
• MGI ID: MGI:2136176
• Synonyms: Agrn^Beta-geo, Agrn^{Gt(p1.8TM)192Wcs}
• Gene: Agrn Location: Chr4:156249747-156281945 bp, - strand Genetic Position: Chr4, 88.55 cM
• Alliance: Agrn^Gt(Ex192)Byg page

Mutation origin

• Mutant Cell Line: Ex192
• Germline Transmission: Earliest citation of germline transmission: J:70273
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Modified isoform(s))
• Mutation: Insertion of gene trap vector Vector: pGT1.8TM
• Mutation details: Insertion of a gene trap construct, pGT1.8TM, into the gene between the two exons encoding the N-terminal seqences of the agrin isoforms. The insertion abolished activity of the long N-terminal basal laminae isoform (LN-agrin) but had no detectable affects on the short N-terminal cell associated isoform (SN-agrin). (J:64996)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  Ex192	CC144395 ; (MGI Seq Detail)	5' RACE	Chr4:156279700-156279826 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  36 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

40 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agrn Mutation: 102 strains or lines available

References

• Original: J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
• All: 6 reference(s)