Ccr4^tm1Pwr
Targeted Allele Detail

Summary

• Symbol: Ccr4^tm1Pwr
• Name: C-C motif chemokine receptor 4; targeted mutation 1, Christine Power
• MGI ID: MGI:2136258
• Synonyms: Ccr4^-, CCR4-
• Gene: Ccr4 Location: Chr9:114319384-114333984 bp, - strand Genetic Position: Chr9, 64.49 cM
• Alliance: Ccr4^tm1Pwr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70088
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire coding sequence and part of the 5' noncoding region. RT-PCR did not amplify transcript from thymus, spleen, or peritoneal macrophage cells of homozygous mutant mice. (J:70088)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr4 Mutation: 30 strains or lines available

References

• Original: J:70088 Chvatchko Y, et al., A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J Exp Med. 2000 May 15;191(10):1755-64
• All: 44 reference(s)