Pitx2^tm1Jfm
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm1Jfm
• Name: paired-like homeodomain transcription factor 2; targeted mutation 1, James F Martin
• MGI ID: MGI:2136268
• Synonyms: delta abc^null, pitx2^hd
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm1Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57674
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 5 and part of exon 6, which encodes the homeobox domain. (J:57674)

Disease models

Expression

In Mice Carrying this Mutation:	80 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 39 strains or lines available

References

• Original: J:57674 Lu MF, et al., Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature. 1999 Sep 16;401(6750):276-8
• All: 27 reference(s)