Pitx2^tm2Jfm
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm2Jfm
• Name: paired-like homeodomain transcription factor 2; targeted mutation 2, James F Martin
• MGI ID: MGI:2136269
• Synonyms: delta ab^hypoc, Pitx2^PZNeo
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm2Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69854
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Hypomorph, Modified isoform(s), Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ cassette followed by a loxP-flanked neomycin resistance cassette replaced a genomic fragment containing the coding region of exon 2 and all of exon 3. This allele encodes the heart- and lung-specific c isoform in the absence of the a and b isoforms. The presence of the retained neomycin resistance cassette results in a hypomorphic allele. (J:69854)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 39 strains or lines available

References

• Original: J:69854 Liu C, et al., Regulation of left-right asymmetry by thresholds of Pitx2c activity. Development. 2001 Jun;128(11):2039-48
• All: 4 reference(s)