Otx1^tm1Asim
Targeted Allele Detail

Summary

• Symbol: Otx1^tm1Asim
• Name: orthodenticle homeobox 1; targeted mutation 1, Antonio Simeone
• MGI ID: MGI:2136272
• Synonyms: Otx1^-
• Gene: Otx1 Location: Chr11:21944764-21952897 bp, - strand Genetic Position: Chr11, 14.1 cM
• Alliance: Otx1^tm1Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35640
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.3kb fragment, including the coding regions of exons 1 and 2, was replaced by a LacZ gene. J:135697 (PMID:18294714) states that mice homozygous for this allele are not "Otx1-complete null" mice, but no details are given. (J:35640)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	53 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Otx1 Mutation: 86 strains or lines available

References

• Original: J:35640 Acampora D, et al., Epilepsy and brain abnormalities in mice lacking the Otx1 gene. Nat Genet. 1996 Oct;14(2):218-22
• All: 17 reference(s)