Rxra^tm3Ipc
Targeted Allele Detail

Summary

• Symbol: Rxra^tm3Ipc
• Name: retinoid X receptor alpha; targeted mutation 3, Pierre Chambon
• MGI ID: MGI:2136273
• Synonyms: HS23.26Cre, RXRalpha af1
• Gene: Rxra Location: Chr2:27566452-27652969 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Rxra^tm3Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Deletion of exon 2 (with the exception of its splicing acceptor site), intron 2, and 102 bp of exon 3. The resulting protein is truncated from amino acid 11-132l. This region contains the autonomous AF-1 activation function and several phosphorylation sites. This is a null mutation for the alpha 2 and 3 isoforms. (J:69853)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxra Mutation: 30 strains or lines available

Notes

A second line of mice (BL19) was established where the floxed selectable marker was excised by crossing heterozygotes with a transgenic mouse expressing CRE under the control of the CMV promoter. Identical phenotypic observations were made in both lines of mice.

References

• Original: J:69853 Mascrez B, et al., Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha. Development. 2001 Jun;128(11):2049-62
• All: 2 reference(s)