Rxra^tm2Ipc
Targeted Allele Detail

Summary

• Symbol: Rxra^tm2Ipc
• Name: retinoid X receptor alpha; targeted mutation 2, Pierre Chambon
• MGI ID: MGI:2136274
• Synonyms: RXR-alpha-
• Gene: Rxra Location: Chr2:27566452-27652969 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Rxra^tm2Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20550
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exon 4 with a PGK-Neo cassette. Western analysis using a polyclonal antibody directed against the N-terminus failed to detect the protein in homozygous mutant animals. (J:20550)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxra Mutation: 30 strains or lines available

Notes

Two ES cell lines were used: D3 and H1

References

• Original: J:20550 Kastner P, et al., Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell. 1994 Sep 23;78(6):987-1003
• All: 16 reference(s)