Tac1^tm1Pig
Targeted Allele Detail

Summary

• Symbol: Tac1^tm1Pig
• Name: tachykinin 1; targeted mutation 1, Pain Investigation Group
• MGI ID: MGI:2136279
• Synonyms: SP-, Tac1^-, Tac^tTAneo
• Gene: Tac1 Location: Chr6:7555061-7562978 bp, + strand Genetic Position: Chr6, 3.31 cM
• Alliance: Tac1^tm1Pig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46179
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced parts of exons 2 and 3. Radioimmunoassay of HPLC fractionated whole brain extracts did not detect protein in homozygous mutant mice. Immunohistochemistry detected almost no immunoreactivity in brain of homozygous mutant mice. (J:46179)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tac1 Mutation: 41 strains or lines available

References

• Original: J:46179 Zimmer A, et al., Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2630-5
• All: 20 reference(s)