Abcb11^tm1Wng
Targeted Allele Detail

Summary

• Symbol: Abcb11^tm1Wng
• Name: ATP-binding cassette, sub-family B member 11; targeted mutation 1, Renxue Wang
• MGI ID: MGI:2136289
• Synonyms: spgp^-
• Gene: Abcb11 Location: Chr2:69068626-69172958 bp, - strand Genetic Position: Chr2, 39.69 cM
• Alliance: Abcb11^tm1Wng page

Hepatocyte and bile canalicular abnormalities in Abcb11^tm1Wng/Abcb11^tm1Wng mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67548
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The N-terminal ATP-binding domain, corresponding to amino acids 454-478, was deleted and replaced with a neo cassette. The construct introduced three missense mutations and a premature stop codon at position 454. Western analysis showed no detectable protein in homozygous mice. (J:67548)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Abcb11 Mutation: 95 strains or lines available

References

• Original: J:67548 Wang R, et al., Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2011-6
• All: 15 reference(s)