Tp(Y)1Ct^Sxr-b
Spontaneous Allele Detail

Summary

• Symbol: Tp(Y)1Ct^Sxr-b
• Name: transposition, Chr Y, Cattanach 1; Sex reversed, b variant
• MGI ID: MGI:2136318
• Synonyms: HY^-, Sxr'
• Gene: Tp(Y)1Ct Location: unknown Genetic Position: ChrY, Syntenic

Mutation origin

• Strain of Origin: T16H stock

Mutation description

• Allele Type: Spontaneous
• Mutations: Deletion, Translocation
• Tp(Y)1Ct^Sxr-b involves 3 genes/genome features (Hya, Zfy1, Zfy2) View all
• Mutation details: At least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy, Zfy1, and Zfy2. The Tp(Y)1Ct^Sxr-b variant retained the testis determining gene, Sry, but lost the H-Y antigen-determining gene, Hya. This chromosomal variant also appears to lack one of the Y-linked zinc finger genes, Zfy1 but retains the other, Zfy2. The formation of Tp(Y)1Ct^Sxr-b from Tp(Y)1Ct^Sxr-a was later shown to be due to unequal crossing over between Zfy1 and Zfy2, resulting in a fusion gene and a small interstitial deletion. XX females carrying this transposition variant are sex-reversed but do not express Y Chromosome linked transplantation antigen, Hya. (J:9332)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	25 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tp(Y)1Ct Mutation: 4 strains or lines available

References

• Original: J:7662 McLaren A, et al., Male sexual differentiation in mice lacking H-Y antigen. Nature. 1984 Dec 6-12;312(5994):552-5
• All: 27 reference(s)