Tp(Y)1Ct^Sxr-a
Spontaneous Allele Detail

Summary

• Symbol: Tp(Y)1Ct^Sxr-a
• Name: transposition, Chr Y, Cattanach 1; Sex reversed, original transposition
• MGI ID: MGI:2136323
• Synonyms: Sxr
• Gene: Tp(Y)1Ct Location: unknown Genetic Position: ChrY, Syntenic

Mutation origin

• Strain of Origin: RIII

Mutation description

• Allele Type: Spontaneous
• Mutation: Translocation
• Mutation details: This cytogenetic transposition comprises a duplication of a Y Chromosome short arm segment, originally from the RIII inbred strain, that was transferred to the distal end of the long arm adjacent to the pseudoautosomal region which normally recombines with the X Chromosome during meiosis. During meiosis the duplicated region from the Y translocates to the X Chromosome of one-half of the X-bearing gametes. Genetic females with a male phenotype result when these gametes fertilize X bearing eggs. At least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy(Sry), Zfy1, and Zfy2. (J:6907, J:9332, J:193163)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tp(Y)1Ct Mutation: 4 strains or lines available

References

• Original: J:5252 Cattanach BM, et al., Sex-reversed mice: XX and XO males. Cytogenetics. 1971;10(5):318-37
• All: 34 reference(s)